International Journal of Dentistry Research 2018; 3(1): 13-16 ; DOI:10.31254/dentistry.2018.3105
Evaluation of salivary contents in oral cancer: A preliminary study
Mohd. Saleem1 , Balasundari Shreedhar2 , Pradkhshana Vijay1 , Mala Kamboj3 , Somi Fatima4 , Faizal Ali5
1. Senior Resident, Department of Oral Pathology and Microbiology, F.O.D.S, KGMU, Lucknow, Uttar Pradesh, India
2. Professor and Head, Department of Oral Pathology and Microbiology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India
3. Professor and Head, Department of Oral Pathology and Microbiology, PGIDS, Rohtak, Haryana, India
4. Post graduate student, Dept. of Oral Medicine and Radiology, Career Postgraduate Institute of Dental sciences and hospital, Lucknow, Uttar Pradesh, India
5. Post graduate student, Department of Oral Pathology and Microbiology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India
*Author to whom correspondence should be addressed.
Received: 20th January, 2018 / Accepted: 28th March, 2018 / Published : 30th April, 2018
Introduction: Salivary levels have been measured in many infections, autoimmune or psychiatric diseases and in various cancers. Salivary components such as kallikrein, epidermal growth factor, CA-125and p53 are used as tumor markers in breast, ovary or lung malignancies. There is short of studies using saliva as a diagnostic fluid for oral cancer. Aim and objective: Estimation of salivary total protein, sialic acid and total sugar in the oral cancer patients. Material and method: Unstimulated saliva was collected from 50 controls (Group I) and 50 oral squamous cell carcinoma patients (group II) and sialic acid, total protein, and total sugar were estimated and compared with the different histological grades. Statistical analysis and Results: Student’s t test and ANOVA was performed for the statistical analysis. The level of salivary protein was lower in Group II compared to Group I. The level of total sugar, free sialic acid and protein bound sialic acid was elevated in Group II than Group I. The total protein and sugar and sialic acid were significantly high in well differentiated squamous cell carcinoma. Conclusion: We conclude that analysis of saliva can help in early diagnosis of oral cancer.
Tumor marker, non-invasive, serum, histopathology.
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