International Journal of Dentistry Research 2020; 5(2): 66-70 DOI:10.31254/dentistry.2020.5208
Comparative Evaluation to Assess the Effect of SRP With or Without Human Placental Extracts as Local Drug Delivery in Treatment of Localized Periodontal Pocket- A Randomized Controlled Clinical Trial
Aakriti Sharma1 , Sanjeev Sharma2 , Amit Nagar3
1. ITS Dental College and Hospitals, Greater Noida, Uttar Pradesh, India
2. Senior Lecturer, Department of Orthodontic & Dentofacial Orthopaedics, Inderprastha Dental College & Hospital, Ghaziabad, Uttar Pradesh, India
3. Professor, Department of Orthodontic & Dentofacial Orthopaedics, King George’s Medical College, Uttar Pradesh, India
*Author to whom correspondence should be addressed.
Received: 22nd April, 2020 / Accepted: 5th June, 2020 / Published : 30th August, 2020
Background: Periodontal disease is one of the most prevalent global chronic disorder. Pathology affecting the structure surrounding teeth results in inflammation initiated by bacterial aggregation & alteration in their profile. Conventional periodontal therapeutics has focused on the control of etiologic agents, thereby promoting healing & repair of tissues. Delivery of therapeutic agents into the local milieu act as drug reservoirs which could alter pathogenic flora & promote its repair & wound healing. Aim & Objective: In an effort to develop a novel therapy, the present study aims to compare clinical soft tissue parameters around periodontal pockets treated with & without human placental extracts delivered locally. Materials & Method: In 10 patients of chronic periodontitis, bilateral localized periodontal pockets of 4-6 mm depth were included. Each site was randomly allocated to group 1 & group 2,where in group 1, scaling & root planing(SRP) was done while in group 2,Placentrex Gel (Human placental extracts) adsorbed on absorbable gelatin matrix (Abgel) used as a vehicle was delivered as an adjunct to SRP . Clinical parameters were recorded & re- evaluated after one month for both the treatment groups . Statistical analysis was carried out to evaluate the effect of Placentrex gel as an adjunct to SRP in treatment of periodontal pockets, Mann Whitney & Paired t test were done. Results: There was a statistically significant improvement in clinical parameters with notable difference in probing depth reduction & gain of clinical attachment level in the treatment group subjected to SRP & Placental extract delivery. Conclusion: Clinical variables showed a greater efficacy of SRP & adjunctive use of placental extracts as compared to conventional treatment by SRP thereby underlying placental extracts usage in the management of periodontal disease condition
Human placental extracts, Periodontal Pockets, Periodontal disease.
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